Otophylloside B

• Description :

  Otophylloside B, a C-21 steroidal glycoside isolated from Qingyangshen. Otophylloside B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Otophylloside B has antiepileptic activity[1][2][3].

• CAS Number :

  [106758-54-7]

• UNSPSC :

  12352005

• Target :

  Amyloid-β

• Type :

  Natural Products

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/qingyangshengenin-b.html

• Purity :

  99.51

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O[C@]([C@@]([C@]1([H])C2)(CC=C3[C@@]1(CC[C@H](O[C@@](O[C@H](C)[C@H]4O[C@@](O[C@H](C)[C@H]5O[C@@](O[C@H](C)[C@H]6O)([H])C[C@H]6OC)([H])C[C@@H]5OC)([H])C[C@@H]4OC)C3)C)O)(CC[C@@]7(O)C(C)=O)[C@@]7([C@@H]2OC(/C=C(C)/C(C)C)=O)C

• Molecular Formula :

  C49H78O16

• Molecular Weight :

  923.13

• References & Citations :

  [1]Li JL, et al. Bioactive C21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole. J Nat Prod. 2015 Jul 24;78 (7) :1548-55.|[2]Yang J, et al. Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease. Nat Prod Bioprospect. 2017 Apr;7 (2) :207-214.|[3]Li X, et al. Antiepileptic C21 steroids from the roots of Cynanchum otophyllum. J Asian Nat Prod Res. 2015;17 (7) :724-32.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported