Otophylloside B

CAT: 0804-HY-N0582Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0582Size:5 mg
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Description
Otophylloside B, a C-21 steroidal glycoside isolated from Qingyangshen. Otophylloside B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Otophylloside B has antiepileptic activity[1][2][3].
CAS Number
[106758-54-7]
UNSPSC
12352005
Target
Amyloid-β
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/qingyangshengenin-b.html
Purity
99.51
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O[C@]([C@@]([C@]1([H])C2)(CC=C3[C@@]1(CC[C@H](O[C@@](O[C@H](C)[C@H]4O[C@@](O[C@H](C)[C@H]5O[C@@](O[C@H](C)[C@H]6O)([H])C[C@H]6OC)([H])C[C@@H]5OC)([H])C[C@@H]4OC)C3)C)O)(CC[C@@]7(O)C(C)=O)[C@@]7([C@@H]2OC(/C=C(C)/C(C)C)=O)C
Molecular Formula
C49H78O16
Molecular Weight
923.13
References & Citations
[1]Li JL, et al. Bioactive C21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole. J Nat Prod. 2015 Jul 24;78 (7) :1548-55.|[2]Yang J, et al. Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease. Nat Prod Bioprospect. 2017 Apr;7 (2) :207-214.|[3]Li X, et al. Antiepileptic C21 steroids from the roots of Cynanchum otophyllum. J Asian Nat Prod Res. 2015;17 (7) :724-32.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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