(+) -Magnoflorine

• Description:

  (+) -Magnoflorine (α-Magnoflorine) is an aporphine alkaloid and antifungal agent. (+) -Magnoflorine can be isolated from the aerial parts of Clematis parviloba. (+) -Magnoflorine shows potent antifungal activities against Penicillium avellaneum UC-4376 with a minimal inhibition amount of 5 μg/disc. (+) -Magnoflorine has significant antifungal activities against T. rubrum and T. mentagrophyte with MIC values of 62.5 μg/mL and 62.5 μg/mL, respectively[1][2].

• Product Name Alternative:

  Magnoflorine; α-Magnoflorine; Thalictrine

• UNSPSC:

  12352005

• Hazard Statement:

  H302+H312+H332

• Target:

  Fungal

• Type:

  Natural Products

• Related Pathways:

  Anti-infection

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Infection; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/magnoflorine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[N+]1(C)CCC2=CC(OC)=C(O)C3=C2[C@]1([H])CC4=CC=C(OC)C(O)=C34

• Molecular Formula:

  C20H24NO4+

• Molecular Weight:

  342.41

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

• References & Citations:

  [1]Chen JH, et al. Aporphine alkaloids from Clematis parviloba and their antifungal activity. Arch Pharm Res. 2009 Jan;32 (1) :3-5. |[2]Luo N, et al. Antifungal activity and potential mechanism of magnoflorine against Trichophyton rubrum. J Antibiot (Tokyo) . 2021 Mar;74 (3) :206-214.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [2141-09-5]