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Suramin

CAT: 804-HY-B0879Size: 1 EachDry Ice: NoHazardous: No
1 EachSelected
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor[1]. Suramin is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM) [2]. Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM) [3][4]. Suramin is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor[5].Suramin efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent[6][7][8].
CAS Number
[145-63-1]
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Apoptosis; Parasite; Phosphatase; Reverse Transcriptase; SARS-CoV; Sirtuin; Topoisomerase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Suramin.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)(O)=O)C4=CC(S(=O)(O)=O)=CC(S(=O)(O)=O)=C34)=O)=CC=C2C)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)(O)=O)C8=CC(S(=O)(O)=O)=CC(S(=O)(O)=O)=C78)=O)=CC=C6C)=O)=CC=C5
Molecular Formula
C51H40N6O23S6
Molecular Weight
1297.28
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
+
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
SIRT1; SIRT2; SIRT5
Citation 01
Behav Brain Res. 2023 Aug 24:452:114548.|Biomicrofluidics. 2019 Nov 21;13 (6) :064117.|Clin Transl Med. 2021 Jun;11 (6) :e485.|Int Immunopharmacol. 2023 Jul:120:110295.|Int Immunopharmacol. 2025 Sep 6:165:115494.|J Bone Miner Metab. 2023 Sep;41 (5) :606-620.|Pharmacol Biochem Behav. 2025 Dec:257:174114.|Adv Sci (Weinh) . 2025 Nov 6:e14842.|Br J Pharmacol. 2021 Dec;178 (23) :4646-4662.|Cell Metab. 2024 Sep 5:S1550-4131 (24) 00334-6.|J Agric Food Chem. 2023 Oct 4;71 (39) :14263-14275.|J Biol Chem. 2020 Jul 24;295 (30) :10281-10292. |J Biol Chem. 2021 Oct;297 (4) :101166.|J Hematol Oncol. 2025 Apr 1;18 (1) :38.|J Med Chem. 2024 Aug 8;67 (15) :12760-12783.|J Virol Methods. 2021 Dec:298:114283.|Lipids Health Dis. 2023 Dec 13;22 (1) :222.|Nat Commun. 2024 Aug 27;15 (1) :7369.|Nat Struct Mol Biol. 2021 Mar;28 (3) :319-325.|Phys Rev Appl. 2025 Jun 06.|Research Square Preprint. 2020 Nov.

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