Dihydroergotoxine (mesylate)

Dihydroergotoxine (mesylate)

• CAS Number: 8067-24-1
• UNSPSC Description: Dihydroergotoxine mesylate is a series of alkaloid salt mixtures with high binding activity to GABAA receptors.
• Target Antigen: GABA Receptor
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/Dihydroergotoxine_mesylate.html
• Purity: 99.88
• Solubility: DMSO : ≥ 100 mg/mL|H2O : 2 mg/mL (ultrasonic)
• Smiles: [H][C@]1([C@]2([H])C[C@@H](C(N[C@@]3(C(C)C)C(N([C@@H]([R])C(N4[C@@]5([H])CCC4)=O)[C@@]5(O)O3)=O)=O)CN1C)CC6=CNC7=C6C2=CC=C7.CCC8=CC=CC=C8.CC(C)C.CC(CC)C.CC(C)CC.OS(=O)(C)=O
• References & Citations: [1]Tvrdeic A, et al. Dihydrogenated ergot compounds bind with high affinity to GABAA receptor-associated Cl- ionophore. Eur J Pharmacol. 1991 Sep 4;202(1):109-11.|[2]Tvrdeic A, et al. Dihydroergotoxine modulation of the GABAA receptor-associated Cl- ionophore in mouse brain. Eur J Pharmacol. 1992 Oct 6;221(1):139-43.|[3]Tvrdeic A, et al. Effect of ergot alkaloids on 3H-flunitrazepam binding to mouse brain GABAA receptors. Coll Antropol. 2003;27 Suppl 1:175-82.|[4]Abdul M, et al. Expression of gamma-aminobutyric acid receptor (subtype A) in prostate cancer. Acta Oncol. 2008;47(8):1546-50.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: Launched