Fenoldopam

• Description :

  Fenoldopam (SKF 82526) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist. Target: D1 Receptor Fenoldopam is a selective dopamine-1 (DA1) agonist with natriuretic/diuretic properties. Fenoldopam stimulated cAMP accumulation in LLC-PK1 cells in a dose-dependent manner, an effect which could be blocked by the DA1-selective antagonist Sch 23390. Although fenoldopam was more potent than DA (EC50 55.5 +/- 7.75 nM vs. 1.65 +/- 0.64 microM) in stimulating cAMP accumulation in LLC-PK1 cells, the maximum stimulation obtained by fenoldopam was only 37% of the maximum stimulation obtained by DA (Emax 13.0 +/- 2.95 pmol/mg of protein vs. 35.6 +/- 10.19 pmol/mg of protein) [1]. Fenoldopam is a selective dopamine1 (DA1) receptor agonist. Most of the DA1 receptor agonist activity of fenoldopam resides in the R-enantiomer, which also shows weaker alpha 2-adrenoceptor antagonist activity Fenoldopam produces vasodilation in vascular beds that are rich in vascular DA1 receptors [2].

• Product Name Alternative :

  SKF 82526

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H317-H319-H334

• Target :

  Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/fenoldopam.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=C(O)C=C2C(C3=CC=C(O)C=C3)CNCCC2=C1Cl

• Molecular Formula :

  C16H16ClNO3

• Molecular Weight :

  305.76

• Precautions :

  P261-P264-P270-P272-P280-P285-P302+P352-P305+P351+P338-P330-P363-P501

• References & Citations :

  [1]Grenader, A. and D.P. Healy, Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther, 1991. 258 (1) : p. 193-8.|[2]Nichols, A.J., R.R. Ruffolo, Jr., and D.P. Brooks, The pharmacology of fenoldopam. Am J Hypertens, 1990. 3 (6 Pt 2) : p. 116S-119S.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Citation 01 :

  Biochem Biophys Res Commun. 2022 Jan 15:588:83-89.|Biomed Pharmacother. 2021 Jul:139:111500.|SLAS Discov. 2020 Sep;25 (8) :895-905.|Cell. 2021 Feb 18;184 (4) :943-956.e18.

• CAS Number :

  [67227-56-9]