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ATXN1 Antibody

CAT: 0013-GTR18126409Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18126409Size:0.1 mg
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Description
ATXN1 Antibody
Product Name Alternative
ATXN1, ataxin 1, ATX1, D6S504E, SCA1, OTTHUMP00000016065, ataxin-1, spinocerebellar ataxia type 1 protein
UniProt
P54253
Immunogen
The immunogen for this antibody is: C-TLKNLKNGSVKKGQ
Target
ATXN1
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Neuroscience
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
500 ug/mL
Form
Liquid
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Peptide ELISA: antibody detection limit dilution 1:32000.Western Blot:Preliminary experiments gave bands at approx 75kDa and 26kDa in Mouse Fetal Brain lysates after 0.5μg/mL antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 84.7kDa according to NP_001186234.1 and 83.8kDa according to NP_033150.2. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands) . We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates? Have any further splice variants/modified forms been reported?
Prediction Reactivity
Bovine, Human, Mouse, Porcine, Rat
Tested Applications
ELISA
NCBI Accession Number
NP_000323.2
Host or Source
Goat
Preservative
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH 7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

UniProtKB · P54253

Ataxin-1

ATX1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P54253
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ATXN1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q17S02, Q9UJG2, Q9Y4J1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingTriplet repeat expansion

Cellular component

CytoplasmNucleus

Molecular function

DNA-bindingRepressorRNA-binding

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Disease

NeurodegenerationSpinocerebellar ataxia

Biological process

TranscriptionTranscription regulation

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