Azelastine

CAT: 0804-HY-B0462A-05Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-B0462A-05Size:50 mg

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Description

Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2[1][2][3][4].

CAS Number

58581-89-8

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Histamine Receptor; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Endocrinology; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/azelastine.html

Concentration

10mM

Purity

99.9200

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N(C2CCN(C)CCC2)N=C(CC3=CC=C(Cl)C=C3)C4=C1C=CC=C4

Molecular Formula

C22H24ClN3O

Molecular Weight

381.90

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Craig La Force. Review of the pharmacology, clinical efficacy, and safety of azelastine hydrochloridel. Expert Rev Clin Immunol. 2005 Jul;1 (2) :191-201.|[2]Mohamed M Elseweidy, et al. Azelastine a potent antihistamine agent, as hypolipidemic and modulator for aortic calcification in diabetic hyperlipidemic rats model. Arch Physiol Biochem. 2020 Jul 2;1-8.|[3]Carlos D. Zappia, et al. Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model. Pharmacol Res Perspect. 2019 Dec; 7 (6) : e00531.|[4]Li Yang, et al. Identification of SARS-CoV-2 entry inhibitors among already approved drugs. Acta Pharmacol Sin. 2020 Oct 28 : 1-7.|[5]Shao-Cheng Liu, et al. Effect of budesonide and azelastine on histamine signaling regulation in human nasal epithelial cells. Eur Arch Otorhinolaryngol. 2017 Feb;274 (2) :845-853.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

H1 Receptor

Citation 01

Phytomedicine. 2023 Jul 25:116:154825.|bioRxiv. 2025 Sep 4.|Pharm Res. 2025 Aug;42 (8) :1315-1329.

Chemical Information

Azelastine

Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a bronchodilator agent, a H1-receptor antagonist, an anti-asthmatic drug, a platelet aggregation inhibitor, an anti-allergic agent and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.

CAS Number	58581-89-8
PubChem CID	2267
IUPAC Name	4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one
Molecular Formula	C22H24ClN3O
Molecular Weight	381.9
XLogP	4.4
Topological Polar Surface Area	35.9
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	27
Formal Charge	0
Complexity	558

SMILES

CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl

InChI

InChI=1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3

InChIKey

MBUVEWMHONZEQD-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 58581-89-8

CID: 2267

Formula: C22H24ClN3O

MW: 381.9

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	381.9
XLogP3	4.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	381.1607901
Monoisotopic Mass	381.1607901
Topological Polar Surface Area	35.9 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	558
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
TRC-A767410-100MG	Azelastine
CS-O-61747	Azelastine-d6
T0211L-01	Azelastine hydrochloride
sc-201096	Azelastine HCl

Azelastine

Chemical Information

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