Bethanechol

• Description:

  Bethanechol (Carbamyl-β-methylcholine), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system[1].

• Product Name Alternative:

  Carbamyl-β-methylcholine

• UNSPSC:

  12352211

• Hazard Statement:

  H302-H312-H332

• Target:

  MAChR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Bethanechol.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(OC(N)=O)C[N+](C)(C)C

• Molecular Formula:

  C7H17N2O2

• Molecular Weight:

  161.22

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

• References & Citations:

  [1]Julia Yuen Hang Liu, et al. Acetylcholine exerts inhibitory and excitatory actions on mouse ileal pacemaker activity: role of muscarinic versus nicotinic receptors. Am J Physiol Gastrointest Liver Physiol. 2020 Jul 1;319 (1) :G97-G107.|[2]M J Fregly, et al. Bethanechol-induced water intake in rats: possible mechanisms of induction. Pharmacol Biochem Behav. 1982 Oct;17 (4) :727-32.|[3]Inderbir S. Padda, et al. Bethanechol. Treasure Island (FL) : StatPearls Publishing; 2020 Jan-.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  MAChR1; mAChR3; mAChR4; mAChR5

• Citation 01:

  Research Square Preprint. 2022 Mar.|Cell Stem Cell. 2025 May 1;32 (5) :778-794.e10.

• CAS Number:

  [674-38-4]