Sitafloxacin

Sitafloxacin

• CAS Number: 127254-12-0
• UNSPSC Description: Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection[1][2].
• Target Antigen: Antibiotic; Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sitafloxacin.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CN([C@H]2[C@@H](F)C2)C3=C(C=C(F)C(N(C[C@H]4N)CC54CC5)=C3Cl)C1=O)O
• Molecular Weight: 409.81
• References & Citations: [1]Okumura R, et al. Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: contribution to reducing in vitro emergence of quinolone-resistant Streptococcus pneumoniae. J Antimicrob Chemother. 2008 Jul;62(1):98-104.|[2]Dhople AM, et al. Activities of sitafloxacin (DU-6859a), either singly or in combination with rifampin, against Mycobacterium ulcerans infection in mice. J Chemother. 2003 Feb;15(1):47-52.Antimicrob Resist Infect Control. 2019 Feb 15;8:40. |Curr Microbiol. 2021 Dec 14;79(1):12.|Infect Drug Resist. 2019 Jan 31;12:345-358.|PLoS One. 2019 Mar 27;14(3):e0213868.|bioRxiv. 2024 Nov 06.
• Shipping Conditions: Room temperature
• Clinical Information: Launched