Sitafloxacin

• Description:

  Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection[1][2].

• Product Name Alternative:

  DU6859a

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/sitafloxacin.html

• Purity:

  99.37

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CN([C@H]2[C@@H](F)C2)C3=C(C=C(F)C(N(C[C@H]4N)CC54CC5)=C3Cl)C1=O)O

• Molecular Formula:

  C19H18ClF2N3O3

• Molecular Weight:

  409.81

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Okumura R, et al. Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: contribution to reducing in vitro emergence of quinolone-resistant Streptococcus pneumoniae. J Antimicrob Chemother. 2008 Jul;62 (1) :98-104.|[2]Dhople AM, et al. Activities of sitafloxacin (DU-6859a), either singly or in combination with rifampin, against Mycobacterium ulcerans infection in mice. J Chemother. 2003 Feb;15 (1) :47-52.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  Quinolone

• Citation 01:

  Antimicrob Resist Infect Control. 2019 Feb 15:8:40.|Curr Microbiol. 2021 Dec 14;79 (1) :12.|Infect Drug Resist. 2019 Jan 31:12:345-358.|PLoS One. 2019 Mar 27;14 (3) :e0213868.|bioRxiv. 2024 Nov 06.

• CAS Number:

  [127254-12-0]