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FGA146

CAT: 0804-HY-161245Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161245Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FGA146 is a dual, selective inhibitor for Mpro and human Cathepsin L, with Kis of 2.19 μM, 0.96 μM and 0.87 μM, for Mal-Mpro, pET21-Mpro and Cathepsin L, respectively. FGA146 reveals an antiviral activity against SARS-CoV-2[1].
UNSPSC
12352005
Target
Cathepsin; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/fga146.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C[C@@H]1CCNC1=O)/C=C/[N+]([O-])=O)[C@H](CC(C)C)NC(C2=CC(C(OC)=CC=C3)=C3N2)=O
Molecular Formula
C24H31N5O6
Molecular Weight
485.53
References & Citations
[1]Medrano FJ, et al., Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2. Commun Chem. 2024 Jan 18;7 (1) :15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin L

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