Naratriptan

• Description :

  Naratriptan is an orally active and selective 5-HT1B/1D receptor agonist. Naratriptan is peripherally active and has good oral bioavailability, inducing cranial artery vasoconstriction by activating 5-HT1B/1D receptors (EC50=0.11 μM for dog basilar artery) . Naratriptan also inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation and reduces sterile inflammation. Naratriptan is mainly used in the research of acute migraine, targeting cranial vascular and neuroinflammatory mechanisms[1][2][3][4].

• Product Name Alternative :

  GR-85548A

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  5-HT Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/naratriptan.html

• Purity :

  98.05

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(CCC1=CC2=C(NC=C2C3CCN(C)CC3)C=C1)(NC)=O

• Molecular Formula :

  C17H25N3O2S

• Molecular Weight :

  335.46

• Precautions :

  H315, H319, H320

• References & Citations :

  [1]Rhoden E, et al. Anti-poliovirus activity of protease inhibitor AG-7404, and assessment of in vitro activity in combination with antiviral capsid inhibitor compounds. Antiviral Res. 2013 May;98 (2) :186-91.|[2]Hoskin KL, et al. The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat. Brain Res. 2004 Feb 13;998 (1) :91-9.|[3]Connor HE, et al. Naratriptan: biological profile in animal models relevant to migraine. Cephalalgia. 1997 May;17 (3) :145-52.|[4]Donaldson C, et al. The role of 5-HT1B and 5-HT1D receptors in the selective inhibitory effect of naratriptan on trigeminovascular neurons. Neuropharmacology. 2002 Mar;42 (3) :374-85.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  5-HT1 Receptor; mLAG-3

• CAS Number :

  [121679-13-8]