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Naloxegol

CAT: 0804-HY-A0118Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-A0118Size:1 Each
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Description
Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation[1][2].
CAS Number
854601-70-0
Product Name Alternative
NKTR-118; AZ-13337019
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Naloxegol.html
Solubility
10 mM in DMSO
Smiles
O[C@@]1(CC[C@H](OCCOCCOCCOCCOCCOCCOCCOC)[C@]2([H])OC3=C4O)[C@]52C3=C(C=C4)C[C@@]1([H])N(CC=C)CC5
Molecular Formula
C34H53NO11
Molecular Weight
651.78
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Yoon SC, et al. Naloxegol in opioid-induced constipation: a new paradigm in the treatment of a common problem. Patient Prefer Adherence. 2017 Jul 24;11:1265-1271.|[2]Garnock-Jones KP, et al. Naloxegol: a review of its use in patients with opioid-induced constipation. Drugs. 2015 Mar;75 (4) :419-25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Front Immunol. 2021 Jul 7:12:692286.|Eur J Pharmacol. 2021 Jul 15:903:174132.

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