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Alosetron

CAT: 0804-HY-70050A-04Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-70050A-04Size:50 mg
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Description
Alosetron (GR 68755) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron is used for the research of irritable bowel syndrome (IBS) . Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects[1][2].
CAS Number
122852-42-0
Product Name Alternative
GR 68755; GR 68755X
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/alosetron.html
Purity
96.26
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C(C1=C2C=CC=C1)=C(N2C)CC3)N3CC4=C(NC=N4)C
Molecular Formula
C17H18N4O
Molecular Weight
294.35
Precautions
H315, H319, H320
References & Citations
[1]Balfour JA, Goa KL, Perry CM. Alosetron. Drugs. 2000;59 (3) :511-520.|[2]Motavallian A, et al. Anti-inflammatory effects of alosetron mediated through 5-HT3 receptors on experimental colitis. Res Pharm Sci. 2019;14 (3) :228-236.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Lactoferrin

Chemical Information

Alosetron

Alosetron is a pyrido[4,3-b]indole compound having a 5-methyl-1H-imidazol-4-ylmethyl group at the 2-position. It has a role as a serotonergic antagonist, an antiemetic and a gastrointestinal drug. It is a member of imidazoles and a pyridoindole.

CAS Number122852-42-0
PubChem CID2099
IUPAC Name5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one
Molecular FormulaC17H18N4O
Molecular Weight294.35
XLogP1.6
Topological Polar Surface Area53.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity442
SMILES
CC1=C(N=CN1)CN2CCC3=C(C2=O)C4=CC=CC=C4N3C
InChI
InChI=1S/C17H18N4O/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2/h3-6,10H,7-9H2,1-2H3,(H,18,19)
InChIKey
JSWZEAMFRNKZNL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Alosetron
CAS: 122852-42-0
CID: 2099
Formula: C17H18N4O
MW: 294.35
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight294.35
XLogP31.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass294.14806121
Monoisotopic Mass294.14806121
Topological Polar Surface Area53.9 Ų
Heavy Atom Count22
Formal Charge0
Complexity442
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A3157-10Alosetron
A3159-10Alosetron Hydrochloride
RM-A121527-01Alosetron-D3
MBS575460Alosetron HCl
A11310-100Alosetron 100mg
A11310-10Alosetron 10mg
A11310-200Alosetron 200mg
A11310-50Alosetron 50mg
A11310-25Alosetron 25mg

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