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Clemizole

CAT: 0804-HY-30234-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-30234-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Clemizole is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. Clemizole is an inhibitor of TRPC5 channel. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 μM.
CAS Number
442-52-4
UNSPSC
12352005
Target
HCV; HCV Protease; Histamine Receptor; TRP Channel
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Clemizole.html
Concentration
10mM
Purity
98.42
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(C=C1)CN2C(CN3CCCC3)=NC4=CC=CC=C24
Molecular Formula
C19H20ClN3
Molecular Weight
325.84
References & Citations
[1]Einav S, et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26 (9) :1019-27|[2]Richter JM, et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86 (5) :514-21|[3]Nishimura T, et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013 Feb;344 (2) :388-96.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor

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