Clemizole

• UNSPSC Description:

  Clemizole is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. Clemizole is an inhibitor of TRPC5 channel. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 μM.

• Target Antigen:

  HCV; HCV Protease; Histamine Receptor; TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;GPCR/G Protein;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Endocrinology; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Clemizole.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=CC=C(C=C1)CN2C(CN3CCCC3)=NC4=CC=CC=C24

• Molecular Weight:

  325.84

• References & Citations:

  [1]Einav S, et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26(9):1019-27|[2]Richter JM, et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21|[3]Nishimura T, et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013 Feb;344(2):388-96.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  442-52-4