Picrasidine I

• Description:

  Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1[1][2].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Reactive Oxygen Species (ROS)

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/picrasidine-i.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=CC=CC2=C1NC3=C2C(OC)=CN=C3C=C

• Molecular Formula:

  C14H12N2O2

• Molecular Weight:

  240.26

• References & Citations:

  [1]Ho HY, et al. Picrasidine I Triggers Heme Oxygenase-1-Induced Apoptosis in Nasopharyngeal Carcinoma Cells via ERK and Akt Signaling Pathways. Int J Mol Sci. 2022 May 29;23 (11) :6103.|[2]Kong L, et al. Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production. Cell Physiol Biochem. 2017;43 (4) :1425-1435.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [100234-59-1]