Polyclonal ETO/RUNX1T1 Antibody

• Description:

  Polyclonal ETO/RUNX1T1 Antibody_x000D_ Catalog number: B2016957_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 5 µl_x000D_ Molecular Weight or Concentration: 68 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -20°C_x000D_ Keywords: CDR, MTG8, AML1T1, ZMYND2, CBFA2T1_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Le XF, Claxton D, Kornblau S, Fan YH, Mu ZM, Chang KS. Characterization of the ETO and AML1-ETO proteins involved in 8;21 translocation in acute myelogenous leukemia Eur J Haematol. 1998 Apr;60(4):217-25._x000D_ 2: Lindberg SR, Olsson A, Persson AM, Olsson I. Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins Eur J Haematol. 2003 Dec;71(6):439-47._x000D_ 3: Barbetti V, Tusa I, Cipolleschi MG, Rovida E, Dello Sbarba P. AML1/ETO sensitizes via TRAIL acute myeloid leukemia cells to the pro-apoptotic effects of hypoxia Cell Death Dis. 2013 Mar 14;4(3):e536._x000D_ 4: Erickson PF, Dessev G, Lasher RS, Philips G, Robinson M, Drabkin HA. ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease Blood. 1996 Sep 1;88(5):1813-23._x000D_ 5: Esposito MT, Zhao L, Fung TK, Rane JK, Wilson A, Martin N, Gil J, Leung AY, Ashworth A, So CW. Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors Nat Med. 2015 Dec;21(12):1481-90._x000D_ 6: Simkins SG, Knapp SL, Brough GH, Lenz KL, Barley-Maloney L, Baker JP, Dekking L, Wai H, Dixon EP. Generation of monoclonal antibodies to the AML1-ETO fusion protein: strategies for overcoming high homology Hybridoma (Larchmt). 2011 Oct;30(5):433-43._x000D_ 7: Ugarte GD, Vargas MF, Medina MA, León P, Necuñir D, Elorza AA, Gutiérrez SE, Moon RT, Loyola A, De Ferrari GV. Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells Blood. 2015 Oct 8;126(15):1785-9._x000D_ 8: Ajore R, Kumar P, Dhanda RS, Gullberg U, Olsson I. The leukemia associated nuclear corepressor ETO homologue genes MTG16 and MTGR1 are regulated differently in hematopoietic cells BMC Mol Biol. 2012 Mar 23;13:11._x000D_ 9: Stuardo M, Nicovani S, Javed A, Gutierrez S. Breakpoint regions of ETO gene involved in (8; 21) leukemic translocations are enriched in acetylated histone H3 J Cell Biochem. 2013 Nov;114(11):2569-76._x000D_ 10: Tanaka K, Tanaka T, Kurokawa M, Imai Y, Ogawa S, Mitani K, Yazaki Y, Hirai H. The AML1/ETO(MTG8) and AML1/Evi-1 leukemia-associated chimeric oncoproteins accumulate PEBP2beta(CBFbeta) in the nucleus more efficiently than wild-type AML1 Blood. 1998 Mar 1;91(5):1688-99._x000D_ _x000D_ Products Related to Polyclonal ETO/RUNX1T1 Antibody can be found at Antibodies

• Short Description:

  Catalog Number: B2016957 (5 µl)_x000D_ Polyclonal ETO/RUNX1T1 Antibody is a high quality polyclonal antibody that specifically targets the ETO (Eight-Twenty-One) protein, also known as RUNX1T1 (Runt-related transcription factor 1; translocated to, 1). This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9007-83-4