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Rosuvastatin-d6 (sodium)

CAT: 0804-HY-17504BS1Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-17504BS1Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rosuvastatin-d6 sodium is deuterium labeled Rosuvastatin sodium. Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
CAS Number
2070009-41-3
UNSPSC
12352005
Hazard Statement
H302
Target
Autophagy; HMG-CoA Reductase (HMGCR)
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Purity
98.60
Solubility
10 mM in DMSO
Smiles
O=C(O[Na])C[C@H](O)C[C@H](O)/C=C/C1=C(C(C([2H])([2H])[2H])C([2H])([2H])[2H])N=C(N(C)S(C)(=O)=O)N=C1C2=CC=C(C=C2)F
Molecular Formula
C22H21D6FN3NaO6S
Molecular Weight
509.56
Precautions
H302
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Chemical Information

Rosuvastatin (D6 Sodium)
CAS Number2070009-41-3
PubChem CID71752109
IUPAC Namesodium (E,3R,5S)-7-[4-(4-fluorophenyl)-6-(1,1,1,3,3,3-hexadeuteriopropan-2-yl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
Molecular FormulaC22H27FN3NaO6S
Molecular Weight509.6
Topological Polar Surface Area152
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count10
Heavy Atom Count34
Formal Charge0
Complexity773
SMILES
[2H]C([2H])([2H])C(C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)[O-])O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C)C([2H])([2H])[2H].[Na+]
InChI
InChI=1S/C22H28FN3O6S.Na/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32;/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30);/q;+1/p-1/b10-9+;/t16-,17-;/m1./s1/i1D3,2D3;
InChIKey
RGEBGDYYHAFODH-HPECXWNWSA-M
Chemical Structure
2D Structure
2D structure of Rosuvastatin (D6 Sodium)
CAS: 2070009-41-3
CID: 71752109
Formula: C22H27FN3NaO6S
MW: 509.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight509.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count10
Exact Mass509.18788968
Monoisotopic Mass509.18788968
Topological Polar Surface Area152 Ų
Heavy Atom Count34
Formal Charge0
Complexity773
Isotope Atom Count6
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
T12759-01Rosuvastatin D6 Sodium
CS-O-06943Rosuvastatin-d6 Sodium
MBS6048486-01Rosuvastatin-d6, Sodium Salt
TRC-R700502-1MGRosuvastatin-d6 Sodium Salt
abx188869-01Rosuvastatin Sodium
RM-R192297-01Rosuvastatin-d6 Sodium Salt discontinued see RG-R192200
MBS5767519Rosuvastatin D3 sodium
TRC-R225340-500MGRosuvastatin Sodium Salt
CS-O-03030Rosuvastatin-d3 Sodium
AR-R11511-01Rosuvastatin EP Impurity G Sodium Salt (ent-Rosuvastatin Sodium Salt)

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