Dexpramipexole

• Description :

  Dexpramipexole (KNS-760704), also called R- (+) -Pramipexole, is a neuroprotective agent and a weak non-ergot dopamine receptor agonist.

• CAS Number :

  [104632-28-2]

• Product Name Alternative :

  (R) -Pramipexole; R- (+) -Pramipexole; KNS-760704

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/dexpramipexole.html

• Purity :

  99.56

• Solubility :

  DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  NC1=NC(CC[C@@H](NCCC)C2)=C2S1

• Molecular Formula :

  C10H17N3S

• Molecular Weight :

  211.33

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Rudnicki SA, Berry JD, Ingersoll E, et al. Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: subgroup analysis of demographic and clinical characteristics. Amyotroph Lateral Scler|[2]Alavian KN, Dworetzky SI, Bonanni L, et al. Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res. 2012 Mar 29;1446:1-11.|[3]Cudkowicz M, Bozik ME, Ingersoll EW, et al. The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nat Med. 2011 Nov 20;17 (12) :1652-6.|[4]Bozik ME, Mather JL, Kramer WG, et al. Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects. J Clin Pharmacol. 2011 Aug;51 (8) :1177-85.|[5]Cheah BC, Kiernan MC. Dexpramipexole, the R (+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Dec;13 (12) :911-20.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched