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Latrunculin A

CAT: 0804-HY-16929Size: 100 μg (237.2 μM x 1 mL in Ethanol)Dry Ice: NoHazardous: No
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CAT#:0804-HY-16929Size:100 μg (237.2 μM x 1 mL in Ethanol)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration[1][2][3][4][5][6].
CAS Number
76343-93-6
Product Name Alternative
LAT-A
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Arp2/3 Complex
Type
Natural Products
Related Pathways
Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/latrunculin-a.html
Concentration
237.2 μM * 1 mL in Ethanol
Purity
98.9
Solubility
10 mM in DMSO
Smiles
O=C1SC[C@@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1
Molecular Formula
C22H31NO5S
Molecular Weight
421.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Fujiwara I, et al. Latrunculin A Accelerates Actin Filament Depolymerization in Addition to Sequestering Actin Monomers. Curr Biol. 2018 Oct 8;28 (19) :3183-3192.e2.|[2]Coué M, et al. Inhibition of actin polymerization by latrunculin A. FEBS Lett. 1987 Mar 23;213 (2) :316-8.|[3]Khalid A El Sayed, et al. Latrunculin A and its C-17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells. J Nat Prod. 2008 Mar;71 (3) :396-402.|[4]Anke Doller, et al. The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking. Exp Cell Res. 2015 Jan 1;330 (1) :66-80.|[5]Hiroo Konishi, et al. Latrunculin a has a strong anticancer effect in a peritoneal dissemination model of human gastric cancer in mice. Anticancer Res. 2009 Jun;29 (6) :2091-7.|[6]Liang Ma, et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015 Jan;25 (1) :24-38.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Natural Products
Clinical Information
No Development Reported

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