Eltoprazine

• Description :

  Eltoprazine (DU 28853) is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine shows antiaggressive and anxiogenic effects[1][2].

• Product Name Alternative :

  DU 28853

• UNSPSC :

  12352005

• Hazard Statement :

  H301-H315-H319-H335

• Target :

  5-HT Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Eltoprazine.html

• Purity :

  95.0

• Solubility :

  DMSO : ≥ 25 mg/mL

• Smiles :

  N1(C2=C3OCCOC3=CC=C2)CCNCC1

• Molecular Formula :

  C12H16N2O2

• Molecular Weight :

  220.27

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

• References & Citations :

  [1]Sijbesma H, et al. Eltoprazine, a drug which reduces aggressive behaviour, binds selectively to 5-HT1 receptor sites in the rat brain: an autoradiographic study. Eur J Pharmacol. 1990 Feb 20;177 (1-2) :55-66.|[2]Rocha B, et al. Chronic mianserin or eltoprazine treatment in rats: effects on the elevated plus-maze test and on limbic 5-HT2C receptor levels. Eur J Pharmacol. 1994 Sep 1;262 (1-2) :125-31.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• Isoform :

  5-HT1 Receptor;5-HT2 Receptor; mLAG-3; α-1 microglobulin

• CAS Number :

  [98224-03-4]