RegisterLogin

PS10

CAT: 0804-HY-121744-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-121744-01Size:5 mg
Selected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (Kd= 239 nM) than for Hsp90 (Kd= 47 μM) [1]. PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy[2].PDK: pyruvate dehydrogenase kinase
CAS Number
[1564265-82-2]
UNSPSC
12352005
Target
PDHK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ps10.html
Purity
98.51
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
OC1=CC(O)=CC2=C1CN(S(=O)(C3=CC=C(O)C=C3O)=O)C2
Molecular Formula
C14H13NO6S
Molecular Weight
323.32
References & Citations
[1]Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket.J Biol Chem. 2014 Feb 14;289 (7) :4432-43.|[2]Wu CY, et al. A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity.J Biol Chem. 2018 Jun 22;293 (25) :9604-9613.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName

Alternative Products

CatalogName
BA8070-5.1PS10
BA8070-5PS10
BA8070-100PS10
MBS5767399-01PS10
T12566-01PS10
BUP23659PS10
BA8070-10PS10
BA8070-50PS10
abx000249-01HIST1H3J (pS10) Antibody
abx025103-01H3 (pS10) Antibody

Popular Products