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BIO8898

CAT: 0804-HY-122663A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122663A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BIO8898 is a potent CD40-CD154 inhibitor. BIO8898 inhibits soluble CD40L binding to CD40-Ig with an IC50 value of 25 μM. BIO8898 inhibits CD40L-induced apoptosis[1].
UNSPSC
12352005
Target
Apoptosis; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bio8898.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)[C@@H](NC(C1=NC(C(N2[C@H](CN3CCCC3)CCC2)=O)=CC(C4=CC(C(NCC5=CC(C6=CC=CC=C6)=CC=C5)=O)=NC(C(N7[C@H](CN8CCCC8)CCC7)=O)=C4)=C1)=O)C9CCCCC9
Molecular Formula
C53H64N8O6
Molecular Weight
909.13
References & Citations
[1]Silvian LF, et al. Small molecule inhibition of the TNF family cytokine CD40 ligand through a subunit fracture mechanism. ACS Chem Biol. 2011 Jun 17;6 (6) :636-47.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TNFRSF5/CD40

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