Mibefradil

CAT: 0804-HY-15553-03Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-15553-03Size:10 mg

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Description

Mibefradil (Ro 40-5967) is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively[1].

CAS Number

116644-53-2

Product Name Alternative

Ro 40-5967

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/mibefradil.html

Purity

99.29

Solubility

10 mM in DMSO

Smiles

O=C(O[C@@]1(CCN(CCCC2=NC3=CC=CC=C3N2)C)[C@@H](C(C)C)C4=C(C=C(F)C=C4)CC1)COC

Molecular Formula

C29H38FN3O3

Molecular Weight

495.63

Precautions

H302, H315, H319, H335

References & Citations

[1]Mehrke G, et al. The Ca (++) -channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. J Pharmacol Exp Ther. 1994 Dec;271 (3) :1483-8.|[2]Brain KL, et al. The sources and sequestration of Ca (2+) contributing to neuroeffector Ca (2+) transients in the mouse vas deferens. J Physiol. 2003 Dec 1;553 (Pt 2) :627-35.|[3]Yu YF, et al. Protection of the cochlear hair cells in adult C57BL/6J mice by T-type calcium channel blockers. Exp Ther Med. 2016 Mar;11 (3) :1039-1044.|[4]Shiue SJ, et al. Chronic intrathecal infusion of T-type calcium channel blockers attenuates CaV3.2 upregulation in nerve-ligated rats. Acta Anaesthesiol Taiwan. 2016 Oct 17. pii: S1875-4597 (16) 30071-6.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

L-type calcium channel; T-type calcium channel

Citation 01

Chemical Information

Mibefradil

Mibefradil is a member of tetralins. It has a role as a T-type calcium channel blocker.

CAS Number	116644-53-2
PubChem CID	60663
IUPAC Name	[(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methoxyacetate
Molecular Formula	C29H38FN3O3
Molecular Weight	495.6
XLogP	5.8
Topological Polar Surface Area	67.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	12
Heavy Atom Count	36
Formal Charge	0
Complexity	709

SMILES

CC(C)[C@H]1C2=C(CC[C@@]1(CCN(C)CCCC3=NC4=CC=CC=C4N3)OC(=O)COC)C=C(C=C2)F

InChI

InChI=1S/C29H38FN3O3/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32)/t28-,29-/m0/s1

InChIKey

HBNPJJILLOYFJU-VMPREFPWSA-N

Chemical Structure

2D Structure

CAS: 116644-53-2

CID: 60663

Formula: C29H38FN3O3

MW: 495.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	495.6
XLogP3	5.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	12
Exact Mass	495.28972024
Monoisotopic Mass	495.28972024
Topological Polar Surface Area	67.5 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	709
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
E7529-1mg	Mibefradil
MBS5753482	Mibefradil dihydrochloride
A12478-10	Mibefradil 10mg
sc-487927	Mibefradil hihydrochloride
FM65086-01	Mibefradil hydrochloride

Mibefradil

Chemical Information

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