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Encenicline

CAT: 0804-HY-15430-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15430-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Encenicline (EVP-6124) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs) .
CAS Number
550999-75-2
Product Name Alternative
EVP-6124
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/EVP-6124.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=C(C(Cl)=CC=C2)S1)N[C@H]3CN4CCC3CC4
Molecular Formula
C16H17ClN2OS
Molecular Weight
320.84
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Prickaerts J, et al. EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors. Neuropharmacology. 2012 Feb;62 (2) :109|[2]Thomas Papouin, et al. Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness. Neuron. 2017 May 17;94:1-15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Citation 01
Journal of High School Science. 2023 Oct 5.|Psychopharmacology. 2019 Apr;236 (4) :1245-1253.|Eur J Pharmacol. 2017 Sep 15:811:110-116.|Faculty of Health Sciences. 2020 Oct.|Neuron. 2017 May 17;94 (4) :840-854.e7.

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