Fosaprepitant

CAT: 0804-HY-14407Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-14407Size:1 Each
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Description
Fosaprepitant (L-785298) is a proagent of Aprepitant (HY-10052) . Fosaprepitant is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV) [1].
CAS Number
[172673-20-0]
Product Name Alternative
L-758298
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/Fosaprepitant.html
Solubility
10 mM in DMSO
Smiles
O=C1N=C(CN2[C@@H](C3=CC=C(F)C=C3)[C@@H](O[C@H](C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)OCC2)NN1P(O)(O)=O
Molecular Formula
C23H22F7N4O6P
Molecular Weight
614.41
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Pranav Prasoon, et al. Role of fosaprepitant, a neurokinin Type 1 receptor antagonist, in morphine-induced antinociception in rats. Indian J Pharmacol. 2016 Jul-Aug; 48 (4) : 394-398.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Cancer Biol Ther. 2019;20 (5) :653-665.|Acta Pharmacol Sin. 2025 Sep 10.|New J Chem. 29th November 2021.

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