Fosaprepitant

• Description :

  Fosaprepitant (L-785298) is a proagent of Aprepitant (HY-10052) . Fosaprepitant is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV) [1].

• Product Name Alternative :

  L-758298

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Neurokinin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Neurological Disease; Endocrinology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Fosaprepitant.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N=C(CN2[C@@H](C3=CC=C(F)C=C3)[C@@H](O[C@H](C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)OCC2)NN1P(O)(O)=O

• Molecular Formula :

  C23H22F7N4O6P

• Molecular Weight :

  614.41

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Pranav Prasoon, et al. Role of fosaprepitant, a neurokinin Type 1 receptor antagonist, in morphine-induced antinociception in rats. Indian J Pharmacol. 2016 Jul-Aug; 48 (4) : 394-398.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Citation 01 :

  Cancer Biol Ther. 2019;20 (5) :653-665.|Acta Pharmacol Sin. 2025 Sep 10.|New J Chem. 29th November 2021.

• CAS Number :

  [172673-20-0]