Fosaprepitant

• UNSPSC Description:

  Fosaprepitant (L-785298) is a proagent of Aprepitant (HY-10052). Fosaprepitant is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV)[1].

• Target Antigen:

  Neurokinin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Neurological Disease; Endocrinology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Fosaprepitant.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N=C(CN2[C@@H](C3=CC=C(F)C=C3)[C@@H](O[C@H](C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)OCC2)NN1P(O)(O)=O

• Molecular Weight:

  614.41

• References & Citations:

  [1]Pranav Prasoon, et al. Role of fosaprepitant, a neurokinin Type 1 receptor antagonist, in morphine-induced antinociception in rats. Indian J Pharmacol. 2016 Jul-Aug; 48(4): 394-398.Cancer Biol Ther. 2019;20(5):653-665.|New J Chem. 29th November 2021.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  172673-20-0