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Vernakalant

CAT: 0804-HY-14182Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14182Size:1 Each
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Description
Vernakalant (RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic. IC50 value: Target:
CAS Number
794466-70-9
Product Name Alternative
RSD1235
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/vernakalant.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C(C=C1)CCO[C@H]2[C@@H](CCCC2)N3CC[C@H](C3)O)OC
Molecular Formula
C20H31NO4
Molecular Weight
349.46
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Dorian, Paul MD et al. The Effect of Vernakalant (RSD1235), an Investigational Antiarrhythmic Agent, on Atrial Electrophysiology in Humans. Journal of Cardiovascular Pharmacology:July 2007 - Volume 50 -Issue 1 - pp 35-40.|[2]Jodene Eldstrom et al. The Molecular Basis of High-Affinity Binding of the Antiarrhythmic Compound Vernakalant (RSD1235) to Kv1.5 Channels. Molecular Pharmacology December 2007 vol. 72 no. 6 1522-1534|[3]Vernakalant. Too dangerous in atrial fibrillation.Prescrire Int. 2012 May;21 (127) :119-22.|[4]Blomstr?m-Lundqvist C, Blomstr?m P.Safety and efficacy of pharmacological cardioversion of atrial fibrillation using intravenous vernakalant, a new antiarrhythmic drug with atrial selectivity.Expert Opin Drug Saf. 2012 Jul;11 (4) :671-9. Epub 2012 May 26.|[5]Bash LD, Buono JL, Davies GM, Martin A, Fahrbach K, Phatak H, Avetisyan R, Mwamburi M.Systematic review and meta-analysis of the efficacy of cardioversion by vernakalant and comparators in patients with atrial fibrillation.Cardiovasc Drugs Ther. 2012 Apr;26 (2) :167-79.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

Alternative Products

CatalogName
MBS132151-01Vernakalant
468641-01Vernakalant Hydrochloride
MBS386874-01Vernakalant (RSD1235)
MBS386083-01Vernakalant HCl
A11603-50Vernakalant 50mg
A11603-10Vernakalant 10mg
RM-V050103-01Vernakalant Impurity 3
RM-V050107-01Vernakalant Impurity 7
A15275-50Vernakalant HCl 50mg
A15275-2Vernakalant HCl 2mg

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