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Guadecitabine

CAT: 0804-HY-13542Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-13542Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Guadecitabine (SGI-110) is a second-generation DNA methyltransferases (DNMT) inhibitor for research of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) [1].
CAS Number
929901-49-5
Product Name Alternative
SGI-110
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
DNA Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SGI-110.html
Purity
98.0
Smiles
O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](COP(O)(O[C@@H]4[C@@H](CO)O[C@@H](N5C=NC(N)=NC5=O)C4)=O)O3)C=N2)NC(N)=N1
Molecular Formula
C18H24N9O10P
Molecular Weight
557.41
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Foulks JM, et al. Epigenetic drug discovery: targeting DNA methyltransferases. J Biomol Screen. 2012 Jan;17 (1) :2-17.|[2]Coral S, et al. Immunomodulatory activity of SGI-110, a 5-aza-2'-deoxycytidine-containing demethylating dinucleotide. Cancer Immunol Immunother. 2013 Mar;62 (3) :605-14.|[3]Chuang JC, et al. S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth. Mol Cancer Ther. 2010 May;9 (5) :1443-50.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
DNA Methyltransferase
Citation 01
Cancer Res. 2020 Jul 15;80 (14) :3046-3056.|Epigenomes. 2021 Dec 14;5 (4) :27.|J Exp Clin Cancer Res. 2023 Mar 18;42 (1) :67.|J Transl Med. 2024 Mar 1;22 (1) :223.|Mol Cell. 2022 Oct 20;82 (20) :3901-3918.e7.|Neoplasia. 2020 May 25;22 (7) :274-282.|University of Siena. Department of Medical Biotechnologies. 2021 May.|bioRxiv. 2024 August 09.|bioRxiv. 2025 February 08.|JID Innov. 2024 Oct 16;5 (2) :100319.|McGill University. 2025.|Research Square Print. January 3rd, 2023.

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