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Rupatadine

CAT: 0804-HY-13511-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13511-01Size:5 mg
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Description
Rupatadine (UR-12592) is a potent, orally active and long-lasting dual PAF/H1 antagonist, with Kis of 0.55 μM and 0.1 μM, respectively. Rupatadine can be used for the research of allergic rhinitis and urticaria[1][2][3].
CAS Number
158876-82-5
Product Name Alternative
UR-12592
UNSPSC
12352005
Hazard Statement
H302, H413
Target
Autophagy; Histamine Receptor
Type
Reference compound
Related Pathways
Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Rupatadine.html
Purity
99.86
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC1=CN=CC(CN2CC/C(CC2)=C3C4=CC=C(Cl)C=C4CCC5=CC=CN=C5\3)=C1
Molecular Formula
C26H26ClN3
Molecular Weight
415.96
Precautions
H302, H413
References & Citations
[1]Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF) . J Pharmacol Exp Ther. 1997 Jan;280 (1) :114-21.|[2]Lv XX, et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013 Jul 15;8 (7) :e68631.|[3]Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res. 2000 Jul;49 (7) :355-60.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor
Citation 01
Biomed Pharmacother. 2024 Jun 4:176:116826.|Pharmaceutics. 2020 Jun 8;12 (6) :525.

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