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(+) -Apogossypol

CAT: 0804-HY-13408Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-13408Size:1 Each
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Description
(+) -Apogossypol is a pan-BCL-2 antagonist. (+) -Apogossypol binds to Mcl-1, Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 μM, respectively.
CAS Number
66389-74-0
Product Name Alternative
Apogossypol; NSC736630
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/__addition__-Apogossypol.html
Solubility
10 mM in DMSO
Smiles
OC1=C2C=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@@]1[C@@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=CC4=C3O
Molecular Formula
C28H32O6
Molecular Weight
462.54
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Wei J, et al. Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins. Mol Cancer Ther. 2009 Apr;8 (4) :904-13.|[2]Zhan W, et al. Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. Mol Med Rep. 2015 Jun;11 (6) :4142-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-xL; Mcl-1

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