Vanoxerine

• Description :

  Vanoxerine (GBR-12909) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM) . Vanoxerine (GBR-12909) binds to the target site on the dopamine transporter (DAT) [1].

• Product Name Alternative :

  GBR 12909; I893

• UNSPSC :

  12352005

• Target :

  Dopamine Transporter

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/vanoxerine.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC1=CC=C(C(C2=CC=C(F)C=C2)OCCN3CCN(CCCC4=CC=CC=C4)CC3)C=C1

• Molecular Formula :

  C28H32F2N2O

• Molecular Weight :

  450.56

• References & Citations :

  [1]Rothman RB, et al. Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction. Biochem Pharmacol. 2008 Jan 1;75 (1) :2-16.|[2]Andersen PH. The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action. Eur J Pharmacol.|[3]Hirate K, et al. Characteristics of the ambulation-increasing effect of GBR-12909, a selective dopamine uptakeinhibitor, in mice. Jpn J Pharmacol. 1991 Apr;55 (4) :501-11.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• Citation 01 :

  Biochem Biophys Res Commun. 2020 May 14;525 (4) :989-996.|Cell. 2025 Oct 24:S0092-8674 (25) 01131-6.|Front Cell Neurosci. 2018 Sep 11:12:309.|Neuron. 2023 May 17;111 (10) :1626-1636.e6.|bioRxiv. 2024 Dec 23:2024.12.22.629999.|Nature. 2024 Aug;632 (8025) :686-694.|University of Groningen. 2016 Jun 1.

• CAS Number :

  [67469-69-6]