Tasisulam

• Description:

  Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization[1].

• Product Name Alternative:

  LY 573636

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H317-H319-H335

• Target:

  Apoptosis; Molecular Glues

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tasisulam.html

• Purity:

  99.77

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C(NS(=O)(C1=CC=C(Br)S1)=O)C2=CC=C(Cl)C=C2Cl

• Molecular Formula:

  C11H6BrCl2NO3S2

• Molecular Weight:

  415.11

• Precautions:

  P261-P264-P271-P272-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

• References & Citations:

  [1]Meier T, et al. Tasisulam sodium, an antitumor agent that inhibits mitotic progression and induces vascular normalization. Mol Cancer Ther. 2011 Nov;10 (11) :2168-78.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [519055-62-0]