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Pseudouridimycin

CAT: 0804-HY-125650Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-125650Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pseudouridimycin (PUM) is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis[1][2].
CAS Number
1566586-52-4
Product Name Alternative
PUM
UNSPSC
12352005
Target
Antibiotic; Bacterial; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pseudouridimycin.html
Purity
96.0
Solubility
10 mM in DMSO
Smiles
O=C1NC(C([C@H]2[C@@H]([C@@H]([C@@H](CNC([C@H](CCC(N)=O)N(C(CNC(N)=N)=O)O)=O)O2)O)O)=CN1)=O
Molecular Formula
C17H26N8O9
Molecular Weight
486.44
References & Citations
[1]Rosenqvist P, et al. Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin. Sci Rep. 2019 Jun 20;9 (1) :8935.|[2]Kunthavai Pavundurai Chandra, et al. Pseudouridimycin-A Potent Nucleoside Inhibitor of the RNA. ACS Omega. 2023 Feb 13;8 (8) :7989-8000.|[3]Maffioli SI, et al. Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell. 2017 Jun 15;169 (7) :1240-1248.e23.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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