Pseudouridimycin

• Description:

  Pseudouridimycin (PUM) is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis[1][2].

• Product Name Alternative:

  PUM

• UNSPSC:

  12352005

• Target:

  Antibiotic; Bacterial; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/pseudouridimycin.html

• Purity:

  96.0

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1NC(C([C@H]2[C@@H]([C@@H]([C@@H](CNC([C@H](CCC(N)=O)N(C(CNC(N)=N)=O)O)=O)O2)O)O)=CN1)=O

• Molecular Formula:

  C17H26N8O9

• Molecular Weight:

  486.44

• References & Citations:

  [1]Rosenqvist P, et al. Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin. Sci Rep. 2019 Jun 20;9 (1) :8935.|[2]Kunthavai Pavundurai Chandra, et al. Pseudouridimycin-A Potent Nucleoside Inhibitor of the RNA. ACS Omega. 2023 Feb 13;8 (8) :7989-8000.|[3]Maffioli SI, et al. Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell. 2017 Jun 15;169 (7) :1240-1248.e23.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [1566586-52-4]