6H05

• Description:

  6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras (G12C) . IC50 value: Target: K-Ras G12C 6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras (G12C) inhibitors [2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Ras

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/6H05.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1CCN(C(CSC2=CC=C(Cl)C=C2)=O)CC1)NCCSSCCN(C)C

• Molecular Formula:

  C20H30ClN3O2S3

• Molecular Weight:

  476.12

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Ostrem JM, et al. K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503 (7477) :548-51.|[2]Lu S, et al. Harnessing allostery: a novel approach to drug discovery. Med Res Rev. 2014 Nov;34 (6) :1242-85.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  K-Ras

• CAS Number:

  [1469338-01-9]