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6H05

CAT: 0804-HY-12408Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12408Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras (G12C) . IC50 value: Target: K-Ras G12C 6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras (G12C) inhibitors [2].
CAS Number
1469338-01-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/6H05.html
Solubility
10 mM in DMSO
Smiles
O=C(C1CCN(C(CSC2=CC=C(Cl)C=C2)=O)CC1)NCCSSCCN(C)C
Molecular Formula
C20H30ClN3O2S3
Molecular Weight
476.12
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Ostrem JM, et al. K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503 (7477) :548-51.|[2]Lu S, et al. Harnessing allostery: a novel approach to drug discovery. Med Res Rev. 2014 Nov;34 (6) :1242-85.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras

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