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PEAQX

CAT: 0804-HY-12294Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12294Size:1 Each
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Description
PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures[1][2].
CAS Number
459836-30-7
Product Name Alternative
NVP-AAM077
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; Caspase; iGluR
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/peaqx.html
Solubility
10 mM in DMSO
Smiles
O=C1C(NC2=C(C(C(P(O)(O)=O)N[C@H](C3=CC=C(Br)C=C3)C)=CC=C2)N1)=O
Molecular Formula
C17H17BrN3O5P
Molecular Weight
454.21
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Auberson YP, et al. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12 (7) :1099-102.|[2]Anastasio NC, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163 (4) :1181-91.|[3]Qian Xu, et al. Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. J Neurol Sci. 2017 May 15;376:166-175.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Citation 01
J Clin Invest. 2019 Sep 3;129 (9) :3864-3876.|Neuroscience. 2018 Nov 1:391:1-12.|Am J Hypertens. 2021 Aug 9;34 (8) :840-850.|bioRxiv. 2025 Sep 27.|Cells. 2023 Apr 22;12 (9) :1212.|Front Neurosci. 2021 Sep 30:15:703044.|Neurosci Bull. 2025 Apr 28.

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