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Vofopitant

CAT: 0804-HY-12142Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12142Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vofopitant is potent tachykinin NK1 receptor antagonist, with pKis of 10.6, 9.5, and 9.8 for human, rat and ferret NK1 receptor, respectively.
CAS Number
168266-90-8
Product Name Alternative
GR 205171
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Vofopitant.html
Purity
99.82
Solubility
10 mM in DMSO
Smiles
COC1=C(CN[C@@H]2[C@H](C3=CC=CC=C3)NCCC2)C=C(N4C(C(F)(F)F)=NN=N4)C=C1
Molecular Formula
C21H23F3N6O
Molecular Weight
432.44
References & Citations
[1]Gardner CJ, et al. GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity. Regul Pept. 1996 Aug 27;65 (1) :45-53.|[2]Loiseau F, et al. Antidepressant-like effects of agomelatine, melatonin and the NK1 receptor antagonist GR205171 in impulsive-related behaviour in rats. Psychopharmacology (Berl) . 2005 Oct;182 (1) :24-32. Epub 2005 Sep 29.|[3]Guiard BP, et al. Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice. J Neurochem. 2004 Apr;89 (1) :54-63.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NK1R

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BA5615-1Vofopitant
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A21543-50Vofopitant dihydrochloride 50mg
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A21543-5Vofopitant dihydrochloride 5mg
A21543-1Vofopitant dihydrochloride 1mg
A21543-100Vofopitant dihydrochloride 100mg
A21543-25Vofopitant dihydrochloride 25mg
A21543-500Vofopitant dihydrochloride 500mg

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