Chrysene

• Description :

  Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H341, H350, H410

• Target :

  Others

• Type :

  Natural Products

• Related Pathways :

  Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/chrysene.html

• Purity :

  99.81

• Solubility :

  DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  C12=CC=CC=C1C=CC3=C4C=CC=CC4=CC=C23

• Molecular Formula :

  C18H12

• Molecular Weight :

  228.29

• Precautions :

  H341, H350, H410

• References & Citations :

  [1]Vaidya S, et al. Degradation of Chrysene by Enriched Bacterial Consortium. Front Microbiol. 2018 Jun 26;9:1333.|[2]Wislocki PG, et al. Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay. Carcinogenesis. 1986 Aug;7 (8) :1317-22.|[3]Jacob J, et al. Monooxygenase induction by various xenobiotics and its influence on rat liver microsomal metabolism of chrysene in comparison to benz[a]anthracene. Cancer Lett. 1987 Jan;34 (1) :91-102.|[4]Tao LP, et al. Chrysene, a four-ring polycyclic aromatic hydrocarbon, induces hepatotoxicity in mice by activation of the aryl hydrocarbon receptor (AhR) . Chemosphere. 2021 Aug;276:130108.|[5]Hodgson RM, et al. Metabolic activation of chrysene in mouse skin: evidence for the involvement of a triol-epoxide. Carcinogenesis. 1983 Dec;4 (12) :1639-43.|[6]Rice JE, et al. Comparative tumor-initiating activity of methylene-bridged and bay-region methylated derivatives of benz[a]anthracene and chrysene. Carcinogenesis. 1988 Dec;9 (12) :2275-8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [218-01-9]