Vinorelbine

• UNSPSC Description:

  Vinorelbine is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

• Target Antigen:

  Autophagy; Microtubule/Tubulin

• Type:

  Natural Products

• Related Pathways:

  Autophagy;Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/vinorelbine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC[C@@]1(C=CCN2CC3)[C@@]2([H])[C@@]3(C(C=C([C@](C4=C5C(C=CC=C6)=C6N4)(C[C@@](C=C(CC)C7)([H])C[N@]7C5)C(OC)=O)C(OC)=C8)=C8N9C)[C@]9([H])[C@](C(OC)=O)(O)[C@@H]1OC(C)=O

• Molecular Weight:

  778.93

• References & Citations:

  [1]Ngan VK, et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol. 2001 Jul;60(1):225-32.|[2]Liu XM, et al. Unique induction of p21(WAF1/CIP1)expression by vinorelbine in androgen-independent prostate cancer cells. Br J Cancer. 2003 Oct 20;89(8):1566-73.|[3]Poirier VJ, et al. Toxicity, dosage, and efficacy of vinorelbine (Navelbine) in dogs with spontaneous neoplasia. J Vet Intern Med. 2004 Jul-Aug;18(4):536-9.|[4]Pierro JA, et al. Phase I clinical trial of vinorelbine in tumor-bearing cats. J Vet Intern Med. 2013 Jul-Aug;27(4):943-8.Am J Cancer Res. 2021 Apr 15;11(4):1428-1445.|Biochem Pharmacol. 2020 May;175:113865.|Cancers (Basel). 2021, 13(13), 3323.|J Bone Oncol. October 2021, 100391.|Microsyst Nanoeng. 7, 38 (2021).|Acta Pharmacol Sin. 2024 Jun 6.|Adv Ther. 2024 Jul 18.|Biochem Biophys Res Commun. 2020 May 21;526(1):154-157.|Cell Mol Immunol. 2023 Jan;20(1):51-64.|EBioMedicine. 2021 Aug 5;70:103510.|Int J Cancer. 2024 Jul 15;155(2):324-338.|iScience. 6 September 2022, 105081.|Sci Adv. 2023 Jun 2;9(22):eadc9273.|Transl Lung Cancer Res. 2024 Oct 31;13(10):2698-2712.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  71486-22-1