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ZK824859

CAT: 0804-HY-114330Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114330Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZK824859 is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively[1].
CAS Number
2271122-53-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
PAI-1; Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ZK824859.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(OC2=C(F)C=C(F)C(O[C@H](CC)C(O)=O)=N2)=CC(C3=CC=CC(CN)=C3)=C1
Molecular Formula
C23H22F2N2O4
Molecular Weight
428.43
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28 (20) :3372-3375.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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555643ZK824859
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A18680-50ZK824859 50mg
A18680-25ZK824859 25mg
A18680-1ZK824859 1mg
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