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PS372424

CAT: 0804-HY-111149Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-111149Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation[1][2].
CAS Number
914291-61-5
UNSPSC
12352005
Hazard Statement
H301
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ps372424.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(C(CCC(C2=CC=CC=C2)=O)=O)CC3=C(C=CC=C3)C1)N[C@H](C(NCC4CCCCC4)=O)CCCNC(N)=N
Molecular Formula
C33H44N6O4
Molecular Weight
588.74
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Boyé K, et al. The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors. Nat Commun. 2017 Nov 17;8 (1) :1571.|[2]O'Boyle G, et al. Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. Proc Natl Acad Sci U S A. 2012 Mar 20;109 (12) :4598-603.|[3]Stroke IL, et al. Identification of CXCR3 receptor agonists in combinatorial small-molecule libraries. Biochem Biophys Res Commun. 2006 Oct 13;349 (1) :221-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR3
Citation 01
Nat Struct Mol Biol. 2024 Apr;31 (4) :610-620.|Immunity. 2025 Aug 12:S1074-7613 (25) 00314-0.

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