Asimadoline

CAT: 0804-HY-107384Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-107384Size:1 Each

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Description

Asimadoline (EMD-61753) is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant) . Asimadoline has low permeability across the blood brain barrier and has peripheral anti-inflammatory actions. Asimadoline ameliorates allodynia in diabetic rats and has the potential for irritable bowel syndrome (IBS) [1][2][3].

CAS Number

153205-46-0

Product Name Alternative

EMD-61753

UNSPSC

12352005

Hazard Statement

H302, H317

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Asimadoline.html

Purity

99.36

Solubility

10 mM in DMSO

Smiles

O[C@H]1CCN(C1)C[C@H](C2=CC=CC=C2)N(C)C(C(C3=CC=CC=C3)C4=CC=CC=C4)=O

Molecular Formula

C27H30N2O2

Molecular Weight

414.54

Precautions

H302, H317

References & Citations

[1]Camilleri M, et al. Asimadoline, a κ-Opioid Agonist, and Visceral Sensation. Neurogastroenterol Motil. 2008 Sep; 20 (9) : 971–979.|[2]Binder W, et al. Involvement of substance P in the anti-inflammatory effects of the peripherally selective kappa-opioid asimadoline and the NK1 antagonist GR205171. Eur J Neurosci. 1999 Jun;11 (6) :2065-72.|[3]C G Jolivalt, et al. Dynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic rats. Diabetologia. 2006 Nov;49 (11) :2775-85.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

κ Opioid Receptor/KOR

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GTR19188420-01	Asimadoline
530139	Asimadoline HCl
C06947-01	Asimadoline hydrochloride
441823	Asimadoline Hydrochlorine
JH919571	Asimadoline-HCl
A16920-25	Asimadoline 25mg
A16920-5	Asimadoline 5mg
A16920-100	Asimadoline 100mg
A16920-50	Asimadoline 50mg
A16920-10	Asimadoline 10mg

Asimadoline

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