Inarigivir

• Description :

  Inarigivir (ORI-9020) is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) act as a RIG-I agonist to activate cellular innate immune responses[1][2].

• CAS Number :

  [475650-36-3]

• Product Name Alternative :

  ORI-9020; SB-9000

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  HBV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/Inarigivir.html

• Purity :

  99.20

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  NC1=C(N=CN2[C@@H]3O[C@H](COP(O[C@H]4[C@@H](OC)[C@H](N5C=CC(NC5=O)=O)O[C@@H]4CO)(S)=O)[C@@H](O)C3)C2=NC=N1

• Molecular Formula :

  C20H26N7O10PS

• Molecular Weight :

  587.50

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Iyer RP, et al. Anti-hepatitis B virus activity of ORI-9020, a novel phosphorothioate dinucleotide, in a transgenic mouse model. Antimicrob Agents Chemother. 2004 Jun;48 (6) :2318-20.|[2]Danni Colledge, et al. The Novel Antiviral Agent Inarigivir Inhibits Both Nucleos (t) ide Analogue and Capsid Assembly Inhibitor Resistant HBV in vitro.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2