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Abaperidone

CAT: 0804-HY-101619-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101619-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Abaperidone is a potent antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM.
CAS Number
183849-43-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Abaperidone.html
Solubility
10 mM in DMSO
Smiles
O=C1C(CO)=COC2=CC(OCCCN3CCC(C4=NOC5=C4C=CC(F)=C5)CC3)=CC=C12
Molecular Formula
C25H25FN2O5
Molecular Weight
452.47
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Bolós J, et al. 7-[3- (1-piperidinyl) propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4- (6-fluoro-1, 2-benzisoxazol-3-yl) -piperidin-1-yl]propoxy]-3- (hydroxymeth yl) chromen -4-one (abaperidone, FI-8602) . J Med Chem. 1998 Dec 31;41 (27) :5402-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
5-HT2 Receptor; D2 Receptor; α-1 microglobulin

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