Mouse BAFF Recombinant Protein

• Description:

  BAFF (B-cell Activation Factor), also known as Tumor Necrosis Factor Superfamily member 13B (TNFSF13B), is expressed in B cell lineage cells and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Mouse BAFF Recombinant Protein is purified b-cell activation factor produced in yeast.

• Synonyms:

  Tumor necrosis factor ligand superfamily member 13B; B-cell-activating factor; BAFF; CD257; Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form; Tnfsf13b; Baff

• Gene Name:

  TNFSF13B

• UniProt:

  Q9WU72

• Tissue Specificity:

  Isoform 2 is expressed in many myeloid cell lines.

• Source:

  Yeast

• Sequence:

  [object Object]

• Applications:

  Cell Culture

• Field of Research:

  Adaptive Immunity, B Cells, Cancer, Cytokines, Growth Factors, Growth Factors/Hormones, Immunology, Innate Immunity, Non-CD, Signal Transduction, TNF Superfamily

• Purification:

  Ion-exchange chromatography.

• Bioactivity:

  In testing.

• Form:

  Lyophilized

• Function:

  Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

• Subcellular Location:

  Cell membrane; Single-pass type II membrane protein.