Mouse VEGF-A Recombinant Protein

CAT: 0519-R00045-4Size: 5 µgDry Ice: NoHazardous: No

1 / 1

CAT#:0519-R00045-4Size:5 µg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

VEGF-A is member of the family of vascular endothelial growth factor (VEGF) proteins, which stimulate vasculogenesis and angiogenesis to restore oxygen supply to tissues. VEGF-A is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor (VPF) . Mouse VEGF-A Recombinant Protein is purified vascular endothelial growth factor A produced in yeast.

Synonyms

Vascular endothelial growth factor A; VEGF-A; Vascular permeability factor; VPF; Vegfa; Vegf

Gene Name

VEGFA

UniProt

Q00731

Tissue Specificity

In developing embryos, expressed mainly in the choroid plexus, paraventricular neuroepithelium, placenta and kidney glomeruli. Also found in bronchial epithelium, adrenal gland and in seminiferous tubules of testis. High expression of VEGF continues in kidney glomeruli and choroid plexus in adults.

Source

Yeast

Sequence

[object Object]

Applications

Cell Culture

Field of Research

Angiogenesis, Cancer, Cancer Metabolism, Cardiovascular, Growth Factors, Growth Factors/Hormones, Metabolism, Metabolism Processes, Pathways and Processes, Response To Hypoxia, Signal Transduction

Purification

Ion-exchange chromatography.

Bioactivity

In testing.

Form

Lyophilized

Function

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis (By similarity) . Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042) .

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Subcellular Location

Isoform VEGF-1: Secreted.

UniProtKB · Q00731

Vascular endothelial growth factor A, long form

VEGFA_MOUSE · Mus musculus

View on UniProt ↗

Primary accession: Q00731
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: Vegfa
Protein existence: 1: Evidence at protein level
Organism: Mus musculus (Mouse)
Taxonomy ID: 10090
Alternative names: L-VEGF
EC number: —
Processing: Precursor
Secondary accessions: F8WH81, O70123, Q66S31, Q6GT23, Q6WZL9

Protein keywords

Coding sequence diversity

Alternative initiationAlternative promoter usageAlternative splicing

Biological process

AngiogenesisDifferentiation

Cellular component

Cell membraneCytoplasmEndoplasmic reticulumExtracellular matrixGolgi apparatusMembraneNucleusSecreted

Molecular function

Developmental proteinGrowth factorHeparin-bindingMitogen

PTM

Disulfide bondGlycoprotein

Technical term

Reference proteome

Related Products

Catalog	Name
R00045-3	Feline VEGF-A Recombinant Protein
R00045-6	Rabbit VEGF-A Recombinant Protein
R00045-8	Swine VEGF-A Recombinant Protein
R00045-2	Equine VEGF-A Recombinant Protein
R00045-1	Canine VEGF-A Recombinant Protein
R00045-5	Ovine VEGF-A Recombinant Protein
R00045-7	Rat VEGF-A Recombinant Protein
PROTQ00731-4	Recombinant Murine VEGF Protein
PROTP16612-3	Recombinant Rat VEGF Protein
PROTP49767-250ug	Human VEGF-C Recombinant Protein

Alternative Products

Catalog	Name
ARP4452-01	Recombinant Mouse VEGF Protein
RP0366M-01	Mouse VEGF-A Recombinant Protein
NBP2-35189-10ug	Recombinant Mouse VEGF 164 Protein
PKSM041180-01	Recombinant Mouse VEGF-A/VEGF164 Protein
GTR19124575-01	Recombinant Mouse VEGF-D Protein
MBS8434428-01	Mouse VEGF Recombinant Protein Lyophilized
GTR18881379	Recombinant Mouse VEGF-A
MBS232360-01	RECOMBINANT MOUSE VEGF
GTR18910304	VEGF-A Recombinant Protein
40-491-001mg	VEGF Recombinant Protein