Progesterone Receptor (Phospho-Ser190) Colorimetric Cell-Based ELISA Kit

• Description:

  The Progesterone Receptor (Phospho-Ser190) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Progesterone Receptor (Phospho-Ser190) protein expression profile in cells. The kit can be used for measuring the relative amounts of Progesterone Receptor (Phospho-Ser190) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Progesterone Receptor (Phospho-Ser190) .

• Synonyms:

  Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3; PGR; NR3C3

• Gene Name:

  PGR

• UniProt:

  P06401

• Reactivity:

  Human

• Tissue Specificity:

  In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region- specific responses to hormonal stimuli.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.

• Molecular Weight:

  98981 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Progesterone receptor

• Subcellular Location:

  Nucleus. Cytoplasm. Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G (1) and G (2) /M phases.