BCL-XL (Phospho-Ser62) Colorimetric Cell-Based ELISA Kit

• Description:

  The BCL-XL (Phospho-Ser62) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor BCL-XL (Phospho-Ser62) protein expression profile in cells. The kit can be used for measuring the relative amounts of BCL-XL (Phospho-Ser62) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on BCL-XL (Phospho-Ser62) .

• Synonyms:

  Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X; BCL2L1; BCL2L, BCLX

• Gene Name:

  BCL2L1

• UniProt:

  Q07817

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Bcl-X (S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X (L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

• Molecular Weight:

  26049 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Bcl-2-like protein 1

• Subcellular Location:

  Isoform Bcl-X (L) : Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity) . Localizes to the centrosome when phosphorylated at Ser-49.