PLCG1 (Phospho-Tyr771) Colorimetric Cell-Based ELISA Kit

• Description:

  The PLCG1 (Phospho-Tyr771) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor PLCG1 (Phospho-Tyr771) protein expression profile in cells. The kit can be used for measuring the relative amounts of PLCG1 (Phospho-Tyr771) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on PLCG1 (Phospho-Tyr771) .

• Synonyms:

  1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1; PLCG1; PLC1

• Gene Name:

  PLCG1

• UniProt:

  P19174

• Reactivity:

  Human, Mouse, Rat

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) . Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.

• Molecular Weight:

  148532 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

• Subcellular Location:

  Cell projection, lamellipodium. Cell projection, ruffle. Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.