TNF Receptor II Colorimetric Cell-Based ELISA

• Description:

  The TNF Receptor II Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor TNF Receptor II protein expression profile in cells. The kit can be used for measuring the relative amounts of TNF Receptor II in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on TNF Receptor II.

• Synonyms:

  Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD120b; Etanercept; Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2; TBP-2; TBPII; TNFRSF1B; TNFBR, TNFR2

• Gene Name:

  TNFRSF1B

• UniProt:

  P20333

• Reactivity:

  Human, Mouse, Rat

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

• Molecular Weight:

  48291 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Tumor necrosis factor receptor superfamily member 1B

• Subcellular Location:

  Isoform 1: Cell membrane; Single-pass type I membrane protein.