Sodium Channel-pan Colorimetric Cell-Based ELISA Kit

• Description:

  The Sodium Channel-pan Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Sodium Channel-pan protein expression profile in cells. The kit can be used for measuring the relative amounts of Sodium Channel-pan in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Sodium Channel-pan.

• Synonyms:

  Sodium channel protein type 1 subunit alpha; Sodium channel protein brain I subunit alpha; Sodium channel protein type I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1; SCN1A; NAC1, SCN1

• Gene Name:

  SCN1A

• UniProt:

  P35498

• Reactivity:

  Human, Mouse, Rat

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na (+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli.

• Molecular Weight:

  228972 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Sodium channel protein type 1 subunit alpha

• Subcellular Location:

  Cell membrane; Multi-pass membrane protein.