HDAC6 Colorimetric Cell-Based ELISA Kit

• Description:

  The HDAC6 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor HDAC6 protein expression profile in cells. The kit can be used for measuring the relative amounts of HDAC6 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on HDAC6.

• Synonyms:

  HD6; HDA6; Histone deacetylase 6; JM21

• Gene Name:

  HDAC6

• UniProt:

  Q9UBN7

• Reactivity:

  Human, Mouse

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity) . Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

• Molecular Weight:

  131419 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Histone deacetylase 6

• Subcellular Location:

  Nucleus. Cytoplasm. Perikaryon. Cell projection, dendrite. Cell projection, axon. It is mainly cytoplasmic, where it is associated with microtubules.